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Therefore, targeted enhancement of the GSH system along with prevention of ferroptosis in the myocardium is a promising therapeutic strategy

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Safety and Open Questions Mechanistic studies have confirmed that 5-Amino-1MQ treatment increases NAD+ levels in adipose tissue and liver, enhances SIRT1 activity, and activates downstream targets including PGC-1 and AMPK

doi: 10.1007/s11010-014-2099-y

doi: 10.1016/j.ymgme.2025.109223

Additionally, lifestyle interventions such as regular physical activity of minimum 150 min per week and pharmacological approaches as discussed in this review could further alleviate TMAO-related complications